細胞システム研究

研究概要

本研究の目標は、生命の基本単位である「細胞」に焦点をあて、細胞の構築と動態を１つのシステムとして理解しようというものです。細胞機能の根幹的な要素を徹底的に解析し、それらがどのように連携して細胞の生命機能が発現されるかを追求するとともに、得られた膨大な部品と素反応の情報を抽出・統合し、細胞機能の試験管内再構成と数理モデリングに取り組みます。ここで得られる成果は、個体発生・進化・疾患等、高次生命現象の理解にむけて大きな基盤を提供するものです。

研究テーマ

1. 細胞核動態研究
2. 細胞コンパートメント動態研究
3. 細胞情報計測・モデリング研究

主要論文

1. Kose, S., Furuta, M., and Imamoto, N. Hikeshi, a nuclear import carrier for Hsp70s, protects cells from heat-shock induced nuclear damage. Cell, in press (2012).
2. Huang, L., Nakai, Y., Kuwahara, I., and Matsumoto, K. PRAS40 is a functionally critical target for EWS repression in Ewing sarcoma. Cancer Res., 72, 1260-1269 (2012).
3. Shintomi, K., and Hirano, T. The relative ratio of condensin I to II determines chromosome shapes. Genes Dev., 25, 1464-1469 (2011).
4. Nakagawa, S., Naganuma, T., Shioi, G., and Hirose, T. Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice. J. Cell Biol., 193, 31-39 (2011).
5. Okamoto, M., Kurokawa, K., Matsuura-Tokita, K., Saito, C., Hirata, R., and Nakano, A. High-curvature domains of the endoplasmic reticulum (ER) are important for the organization of ER exit sites in Saccharomyces cerevisiae. J. Cell Sci., in press (2012).
6. Abe, M., Makino, A., Hullin-Matsuda, F., Kamijo, K., Ohno-Iwashita, Y., Hanada, K., Mizuno, H., Miyawaki, A., and Kobayashi, T. A role for sphingomyelin-rich lipid domains in the accumulation of PIP2 to the cleavage furrow during cytokinesis. Mol. Cell Biol., 32, 1396-1407 (2012).
7. Morishima, N., Nakanishi, K., and Nakano, A. Activating transcription factor-6 (ATF6) mediates apoptosis with reduction of myeloid cell leukemia sequence 1 (Mcl-1) protein via induction of WW domain binding protein 1. J. Biol. Chem., 286, 35227-35235 (2011).
8. Hibino, K., Shibata, T., Yanagida, T., and Sako, Y. Activation kinetics of RAF protein in the ternary complex of RAF, RAS-GTP, and kinase on the plasma membrane of living cells: single-molecule imaging analysis. J. Biol. Chem. 286, 36460-36468 (2011).
9. Mochizuki, A., and Saito, D. Analyzing steady states of dynamics of bio-molecules from the structure of regulatory networks. J. Theor. Biol., 266, 323-335 (2010).
10. Nakakuki, T., Birtwistle, M.R., Saeki, Y., Yumoto, N., Ide, K., Nagashima, T., Brusch, L., Ogunnaike, B.A., Okada-Hatakeyama, M., and Kholodenko, B.N. Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics. Cell. 141, 884-896 (2010).

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