Molecular Ensemble Research

Summary

This interdisciplinary research project is aiming to understand exquisite behaviors of the biological systems and molecular-based materials (conductors, magnets, ...etc.) in terms of the non-covalent interactions and their changes at atomic and molecular levels. Our final goal is to design and create a highly organized and functionalized molecular system, each component of which is joined to each other by a variety of weak non-covalent interactions. We call such a system "Molecular Ensemble".

Research Subjects

1. Basic researches toward molecular devices
2. Functional Analyses of weak-interactions in bio-macromolecules ensembles
3. Developments of ultra-high resolution, ultra-high-sensitive and ultra-fast spectroscopy apparatus

Selected Publications

1. Sakakibara, D., Sasaki, A., Ikeya, T., Hamatsu, J., Hanashima, T., Mishima, M., Yoshimasu, M., Hayashi, N., Mikawa, T., Walchli, M., Smith, B. O., Shirakawa, M., Gruntert, P., Ito, Y., Protein Structure Determination in Living cells by In-cell NMR Spectroscopty, Nature 458, 102-105 (2009).
2. Kawasugi, Y., Yamamoto, H. M., Tajima, N., Fukunaga, T., Tsukagoshi, K., Kato, R., Field-Induced Carrier Delocalization in the Strain-Induced Mott Insulating state of an Organic Superconductor, Phys. Rev. Lett., 103(11), 116801/1-4 (2009).
3. Harada, Y., Taguchi, M., Miyajima, Y., Tokushima, T., Horikawa, Y., Chainani, A., Shiro, Y., Senba, Y., Ohashi, H., Fukuyama, H., Shin, S., Ligand Energy Controls the Heme-Fe Valence in Aqueous Myoglobins, J. Phys. Soc. Jpn., 78(4), 044802/1-5 (2009).
4. Sen, S., Yamaguchi, S., Tahara, T., Different Molecules Experience Different Polarities at the Air/Water Interface, Angew. Chem. Int. Ed., 48, 6439-6442 (2009).
5. Yamada, S., Sugimoto, H., Kobayashi, M., Ohno, A., Nakamura, H., Shiro, Y., Structure of PAS-Linked Histidine KInase and the Response Regulator Complex, Structure, 17,1333-1344 (2009).
6. Kawai, K., Saito, A., Sudo,T., Osada, H., Specific Regulation of Cytokine p38 MAP Kinase Activation by p62/SQSTM1, J. Biochem., 143, 765-772 (2008).
7. Yousufuddin, M., Gutmann, M. J., Baldamus, J., Tardif, O., Hou, Z., Mason, S. A., McIntyre, G. J., Bau, R., Neutron Diffraction Studies on a 4-Coordinate Hydrogen Atom in an Yttrium Cluster, J. Am. Chem. Soc., 130, 3888-3891 (2008).
8. Yamamoto, H. M., Kosaka, Y., Maeda, R., Yamaura, J., Nakao, A., Nakamura, T., Kato, R., Supramolecular Insulating Networks Sheathing Conducting Nanowires Based on Organic Radical Cations, ACS Nano, 2(1), 143-155 (2008).
9. Hosoi, H., Yamaguchi, S., Mizuno, H., Miyawaki, A., Tahara, T., Hidden Electronic State of Enhanced Green Fluorescence Protein, J. Phys. Chem. B., 112, 2761-2763 (2008).
10. Mizuno, H., Kumar Mal T., Walchli M ., Kikuchi, A., Fukano, T., Ando, R., Jeyakanthan J., Taka, J., Shiro, Y., Ikura, M., Miyawaki, A., Light-dependent Regulation of Structural Flexibility in a Photochromic Fluorescent Protein, Proc. Natl. Acad. Sci. USA., 105, 9927-9932 (2008).
    

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