Lipid Dynamics

Summary

Lipids are emerging as the last target of post-genome era. Accumulating evidence indicates the importance of lipids in most of the biological phenomena. However, their study has been hampered by the lack of appropriate techniques. Taking advantage of the outstanding scientists working in physics to biology field at RIKEN, we are developing a new and challenging approach to apprehend lipid science through an extensive interdisciplinary collaboration.

Research Subjects

1. Imaging Lipids
2. Lipid Functions
3. Molecular Behavior of Lipids

Selected Publications

1. Matsunaga, S., Matsunaga, T., Iwamoto, T.K., Yamada, T., Shibayama, M., Kawai, M., and Kobayashi, T., Visualization of phospholipid particle fusion induced by duramycin., Langmuir 25, 8200-8207 (2009).
2. Kinoshita, MO., Furuya, S., Ito, S., Shinoda, Y., Yamazaki, Y., Greimel, P., Ito, Y., Hashikawa, T., Machida, T., Nagatsuka, Y., and Hirabayashi, Y., Lipid rafts enriched in phosphatidylglucoside direct astroglial differentiation by regulating tyrosine kinase activity of epidermal growth factor receptors., Biochem J. 419, 565-75 (2009).
3. Baba, A., Akagi, K., Takayanagi, M., Flanagan, JG., Kobayashi, T., and Hattori, M., Fyn tyrosine kinase regulates the surface expression of GPI-linked ephrin, via the modulation of sphingomyelin metabolism.,
   J. Biol. Chem. 284, 9206-9214 (2009).
4. Kohyama-Koganeya, A., Kim, YJ., Miura, M., and Hirabayashi, Y., A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: loss of boss causes abnormal energy metabolism., Proc. Natl. Acad. Sci. U S A. 105, 15328-33 (2008).
5. Takahashi, M., Murate, M., Fukuda, M., Sato, SB., Ohta, A., and Kobayashi, T., Cholesterol controls lipid endocytosis through Rab11., Mol. Biol. Cell 18, 2667-2677 (2007).
6. Hayakawa, T., Makino, A., Murate, M., Sugimoto, I., Hashimoto, Y., Takahashi, H., Ito, K., Fujisawa, T., Matsuo, H., and Kobayashi, T., pH-dependent formation of membranous cytoplasmic body-like structure of ganglioside GM1/bis(monoacylglycero)phosphate mixed membranes., Biophys. J. 92, L13-16 (2007).
7. Iwamoto, K., Hayakawa, T., Murate, M., Makino, A., Ito, K., Fujisawa, T., and Kobayashi, T., Curvature-dependent recognition of ethanolamine phospholipids by duramycin and cinnamycin., Biophys. J. 93, 1608-1619 (2007)
8. Hullin-Matsuda, F., Ishitsuka, R., Takahashi, M., Kobayashi, T., Imaging lipid membrane domains with lipid-specific probes., Methods Mol Biol. 580:203-220 (2009) Review.
9. Nagatsuka, Y. and Hirabayashi, Y., Phosphatidylglucoside: a new marker for lipid rafts., Biochim. Biophys. Acta. 1780, 405-9 (2008) Review.

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