Yu Initiative Research Unit

Initiative Research Scientist

Hsiao-hua Yu

  • Ph.D.
  • Hsiao-hua Yu
  • Brief resume
    2003
    Ph.D., Massachusetts Institute of Technology, USA
    2003
    Postdoctoral Research Associate, Department of Chemical Engineering, Institute for Soldier Nanotechnologies, Massachusetts Institute of Technology, USA
    2004
    Team Leader/Senior Research Scientist, Institute of Bioengineering and Nanotechnology, Singapore
    2008
    Initiative Research Scientist, Yu Initiative Research Unit, RIKEN (-current)
    2010
    Coordinate Associate Professor, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology (-current)

Outline

Yu Initiative Research Unit

Research in our unit targets on the development of a multidisciplinary program involving the triad of chemistry, electronic materials, and biomedical/biological investigations based on molecular and nano-assembled building blocks of organic conductive materials. These materials introduce electrical characteristics to build up the complexity necessary for further understanding of the targeted biological/biomedical issues. They also enlarge the dimensions of synthetic organic chemistry and polymer chemistry. Eventually our research effort would be engaged toward new areas in biomaterials science and engineering through the angle of synthetic organic chemistry.

Recent Research Topic

Organic conductive biomaterials and biointerfaces

Our unit has utilized conducting polymers as a template to construct organic conductive materials. Although many applications of conductive polymers have been demonstrated feasible, there has been only limited research toward biological and biomedical applications based on the non-functionalized forms of conducting polymers. We have synthesized various molecular building blocks based on polyethylenedioxythiophene (PEDOT), one of the most stable conducting polymers. A variety of nanostructures have also been assembled. In the preliminary experiments, these materials have shown promising biocompatibility and electrical properties.

Schematic representation of organic conductive biomaterials
Fig. 1 Schematic representation of organic conductive biomaterials
Application of functionalized PEDOTs as nanobiointerfaces
Fig. 2 Application of functionalized PEDOTs as nanobiointerfaces

Selected Publications

  1. C.-Y. Liu, H. Zhao, H.-h. Yu, Efficient Synthesis of 3,4-Ethylenedioxythiophene (EDOT)-Based Functional π-Conjugated Molecules through Direct C-H Bond Arylations, Org. Lett. 2011, 13, 4068.
  2. E. Mohamed Ali, E. A. B. Kantchev, H. -h. Yu, J. Y. Ying, Electropolymerization of intercalator-grafted conducting polymer for direct and amplified DNA detection, Chem. Commun. 2011, 47, 1533.
  3. S. -C. Luo, S. S. Liour, H. -h. Yu, Perfluoro-functionalized PEDOT films with controlled morphology as superhydrophobic coatings and biointerfaces with enhanced cell adhesion, Chem. Commun. 2010, 46, 4731.
  4. S. -C. Luo, H. Xie, N. Chen, H. –h. Yu, Trinity DNA detection platform by ultrasmooth and functionalized PEDOT biointerfaces, ACS Applied Materials & Interfaces 2009, 1, 1414.
  5. H. Xie, S. -C. Luo, H. -h. Yu, Electric-filed assisted growth of functionalized poly (3, 4-ethylenedioxythiophene) nanowires for label-free protein detection, Small 2009, 5, 2611.
  6. S. -C. Luo, J. Jiang, S. Liour, S. Gao, J. Y. Ying, H. -h. Yu, Magnetic PEDOT hollow capsules with single holes, Chem. Comm. 2009, 2664.
  7. Y. Shi, et al. Work function engineering of electrodes via electropolymerization of ethylenedioxythiophenes and its derivatives, Organic Electronics 2008, 9, 859.
  8. S. -C. Luo, A. C. A. Wan, Y. Han, H. -h. Yu, J. Y. Ying, A general route for functional PEDOT coating on non-conductive surface and hollow particles with single hole via aqueous chemical polymerization, Small 2008, 4, 2051.
  9. S. -C. Luo, et al. PEDOT nanobiointerfaces: thin, ultrasmooth, and functionalized poly(3,4-ethylenedioxythiophene) films with in vitro and in vivo biocompatibility, Langmuir 2008, 24, 8071.
  10. E. Mohamed Ali, E. A. B. Kantchev, H. -h. Yu, J. Y. Ying, Conductivity shift of polyethylenedioxythiophenes (PEDOTs) in aqueous solutions from side-chain charge perturbation, Macromolecules 2007, 40, 6025.

Core Members

Principal Investigator add delete
Hsiao-hua Yu Initiative Research Scientist    
Staff Scientist add delete
Shyh-Chyang Luo ASI Research Scientist 2012.4.1  
Haichao Zhao ASI Research Scientist 2012.4.1  
Postdoctoral Fellow add delete
Bo Zhu Special Postdoctoral Researcher    
Student Trainee add delete
Hsing-An Lin International Program Associate    
Technical Assistant add delete
Jun Sekine Technical Staff I    
Administrative Assistant add delete
Visiting Research Staff add delete
Other Staff add delete
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