Disease Glycomics Team

Team Leader

Naoyuki Taniguchi

  • D.Med.
  • Naoyuki Taniguchi
  • Brief resume
    1972
    D.Med., Hokkaido University
    1976
    Visiting Associate Professor, Cornell University, USA
    1978
    Associate Professor, Hokkaido University
    1986
    Professor/Chair, Osaka University
    2006
    Professor Emeritus/Endowed Chair Professor, Research Institute for Microbial Diseases, Osaka University
    2007
    Group Director, Systems Glycobiology Research Group, RIKEN (-current)
    2009
    Endowed Chair Professor, Institute of Scientific and Industrial Research, Osaka University
    2011
    Guest Professor, Institute of Scientific and Industrial Research, Osaka University (-current)
    2011
    Team Leader, Disease Glycoprobe Team, RIKEN (-current)

Outline

Disease Glycomics Team

Most membrane receptors are glycoproteins, but research on the roles of their glycans is very limited. We recently found that these glycans directly or indirectly play pivotal roles as intra- and internal-cell signaling molecules under physiological and disease conditions and are also involved in gene expression. We analyzed the role of glycans in development and differentiation under physiological conditions, and impaired signals in the lifestyle-related diseases such as COPD, tumor angiogenesis and Alzheimer's disease.

Recent Research Topic

α2,6-Sialic acid-deficient endothelial cells
Fig. 1: α2,6-Sialic acid-deficient endothelial cells
α2,6-Sialic acid-deficient endothelial cells showed the impaired cell surface residency of PECAM.
Fig. 1
Reproduced, with permission, from S. Kitazume, et al. α2,6-Sialic Acid on Platelet Endothelial Cell Adhesion Molecule (PECAM) Regulates Its Homophilic Interactions and Downstream Antiapoptotic Signaling, J. Biol. Chem. 2010, 285, 6515. © (2012) American Society for Biochemistry and Molecular Biology

Selected Publications

  1. Y. Wada, et al. Comparison of Methods for Profiling O-glycosylation: HUPO Human Disease Glycomics/Proteome Initiative Multi-Institutional Study of IgA1, Mol. Cell. Proteomics 2010, 9, 719.
  2. S. Kitazume, et al. Brain Endothelial Cells Produce Amyloid β from Amyloid Precursor Protein 770 and Preferentially Secrete the O-Glycosylated Form, J. Biol. Chem. 2010, 285, 40097.
  3. S. Kitazume, et al. Alpha2,6-sialic acid on platelet endothelial cell adhesion molecule (PECAM) regulates its homophilic interactions and downstream antiapoptotic signaling, J. Biol. Chem. 2010, 285, 6515.
  4. K. Nakajima, et al. Simultaneous determination of nucleotide sugars involved in glycosylation with ion-pair reversed –phase HPLC, Glycobiol. 2010, 20, 865.
  5. N. Taniguchi, From the gamma-glutamyl cycle to the glycan cycle: a road with many turns and pleasant surprises, J. Biol. Chem. 2009, 284, 34469.
  6. S. Kitazume, et al. Molecular insights into β-galactoside α2,6-sialyltransferase secretion in vivo, Glycobiol. 2009, 19, 479.
  7. Y. Tachida, et al. Interleukin-1β up-regulates TACE to enhance -cleavage of APP in neurons: resulting decrease in Aβproduction, J. Neurochem. 2008, 204, 1387.
  8. N. Taniguchi, A sugar-coated switch for cellular growth and arrest, Nature Chem. Biol. 2007, 3, 307.

Core Members

Principal Investigator add delete
Naoyuki Taniguchi Team Leader (Group Director, Systems Glycobiology Research Group)    
Staff Scientist add delete
Shinobu Kitazume Deputy Team Leader    
Kazuaki Ohtsubo Deputy Team Leader    
Kenji Kanekiyo ASI Research Scientist    
Ayako Kurimoto ASI Research Scientist    
Congxiao Gao ASI Research Scientist    
Hiroaki Korekane ASI Research Scientist    
Postdoctoral Fellow add delete
Satoshi Kobayashi Postdoctoral Researcher    
Yasuhiko Kizuka Postdoctoral Researcher    
Student Trainee add delete
Kyohei Okahara Junior Research Associate    
Technical Assistant add delete
Yuriko Tachida Technical Staff I    
Emi Ito Technical Staff I    
Reiko Fujinawa Technical Staff I    
Rie Imamaki Technical Staff I    
Fumi Ota Technical Staff I    
Keiichi Yoshida Technical Staff II    
Shinji Takamatsu Technical Staff II 2012.4.1  
Administrative Assistant add delete
Izumi Funayama Assistant    
Izumi Sugase Assistant    
Visiting Research Staff add delete
Other Staff add delete
Masahiro Sano Part-timer1    
Akemi Suzuki Part-timer2    
Kazuko Ogawa Part-timer2    
Shiho Kobayashi Part-timer2    

( ) indicates primary affiliation in RIKEN.

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