Disease Glycoprobe Team

Team Leader

Naoyuki Taniguchi

  • D.Med.
  • Naoyuki Taniguchi
  • Brief resume
    1972
    D.Med., Hokkaido University
    1976
    Visiting Associate Professor, Cornell University, USA
    1978
    Associate Professor, Hokkaido University
    1986
    Professor/Chair, Osaka University
    2006
    Professor Emeritus/Endowed Chair Professor, Research Institute for Microbial Diseases, Osaka University
    2007
    Group Director, Systems Glycobiology Research Group, RIKEN (-current)
    2009
    Endowed Chair Professor, Institute of Scientific and Industrial Research, Osaka University
    2011
    Guest Professor, Institute of Scientific and Industrial Research, Osaka University (-current)
    2011
    Team Leader, Disease Glycoprobe Team, RIKEN (-current)

Outline

Disease Glycoprobe Team

We promote interdisciplinary research projects to study glycan-related cancers and infectious diseases through multiple approaches combining glycobiology, chemical biology, structural biology and bioinformatics. Intense attention is paid to glycan structures, which are closely related to cancer metastasis and progression. We aim to develop inhibitors for cancer-related glycosyltransferases. In addition, we analyze the binding mode of antibodies or lectins toward glycan-based cancer antigens. Structural information obtained will be used for exploiting the bioprobes specialized for the diagnosis of various cancers. Furthermore, we establish a basis for the development of therapeutics for COPD by understanding the relationship between glycan and pathogenesis.

Recent Research Topic

Substrate-mimicking inhibitors for glycosyltransferase, GnT-V
Fig. 1: Substrate-mimicking inhibitors for glycosyltransferase, GnT-V

Selected Publications

  1. N. Taniguchi, From the gamma-glutamyl cycle to the glycan cycle: a road with many turns and pleasant surprises, J. Biol. Chem. 2009, 284, 34469.

Core Members

Principal Investigator add delete
Naoyuki Taniguchi Team Leader (Group Director, Systems Glycobiology Research Group)    
Staff Scientist add delete
Takashi Angata (Team Leader, Glycan Recognition Team)    
Yoshiki Yamaguchi (Team Leader, Structural Glycobiology Team)    
Tadashi Suzuki (Team Leader, Glycometabolome Team)    
Shinobu Kitazume (Deputy Team Leader, Disease Glycomics Team)    
Kazuaki Ohtsubo (Deputy Team Leader, Disease Glycomics Team)    
Shinya Hanashima ASI Research Scientist (ASI Research Scientist, Structural Glycobiology Team)    
Postdoctoral Fellow add delete
Satoshi Kobayashi Postdoctoral Researcher (Postdoctoral Researcher, Disease Glycomics Team)    
Yasuhiko Kizuka Postdoctoral Researcher (Postdoctoral Researcher, Disease Glycomics Team)    
Student Trainee add delete
Technical Assistant add delete
Administrative Assistant add delete
Visiting Research Staff add delete
Other Staff add delete

( ) indicates primary affiliation in RIKEN.

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