Chemical Biology Department
Director
Hiroyuki Osada
- Brief resume
- 1983
- D.Agr., University of Tokyo
- 1983
- Research Scientist, Antibiotics Laboratory, RIKEN
- 1992
- Chief Scientist, Antibiotics Laboratory, RIKEN (-current)
- 2008
- Director, Chemical Biology Department, RIKEN (-current)
- 2009
- Laboratory Director, Chemical Biology Core Facility, RIKEN (-current)
- 2011
- Director, RIKEN-Max Planck Joint Research Center, RIKEN (-current)
- 2011
- Team Leader, Bioprobe Application Team, RIKEN (-current)
- 2011
- Team Head, RIKEN-KRIBB Joint Research Team, RIKEN (-current)
- 2011
- Team Head, RIKEN-USM Joint Research Team, RIKEN (-current)
Outline
“Chemical Biology” approaches biological questions using chemistry techniques. The approach enables us to understand complex biological systems that have previously been considered difficult in molecular biology, and thus has great potential for contribution to discoveries of new phenomena and mechanisms.
We aim to integrate approaches from such disparate fields as organic chemistry, molecular biology, glycobiology and structural biology into our chemical biology research and reveal some of the mysteries of biological systems. To this end we are engaged in constructing a chemical library of microbial metabolites, and high-throughput screening using enzymes, fission yeasts and mammalian cells. We also aim to reveal the mechanisms of post-translational modification and quality control of proteins, important matters for resolution in the post-human genome project era. We hope also to learn to regulate such activities.
Research Groups
- Laboratory Director
- Hiroyuki Osada
To promote “Chemical Biological Research”
that aims to elucidate biological phenomena using chemical compounds as starting materials, chemical libraries and databases that describe the chemical and biological information of the libraries must be appropriately maintained.
- Group Director
- Minoru Yoshida
Our Group focuses on the development of a variety of original assay systems using newly identified genes, proteins and cell lines, and on the discovery of unique compounds (molecular ligands) that target specific biological molecules.
- Group Director
- Naoyuki Taniguchi
This project focuses on the structure and functions of glycoproteins, and we aim to elucidate (1) abnormality of signaling via membrane receptor glycans, and underlying disease mechanism; (2) novel metabolic pathways of free glycans and then roles in the quality control of glycoproteins; (3) tertiary structures of glycans and their roles in molecular recognition; and (4) to develop single-molecule imaging of glycans.
- Director
- Hiroyuki Osada
Exchanges of researchers and their resources between Max Planck Institutes (groups of Prof. Herbert Waldmann and Prof. Peter Seeberger) and RIKEN ASI promote more effective use of research resources as well as information and technology in the field of systems chemical biology.
Core Members
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( ) indicates primary affiliation in RIKEN. Please see Research Group page for other members.
Chemical Biology Core Facility
Chemical Genomics Research Group
Systems Glycobiology Research Group
RIKEN-Max Planck Joint Research Center