Molecular Characterization Team

Team Head

Hiroyuki Koshino

  • D.Agr.
  • Hiroyuki Koshino
  • Brief resume
    1990
    D.Agr., Hokkaido University
    1990
    Special Postdoctoral Researcher, Antibiotics Laboratory, RIKEN
    1992
    Research Scientist, Molecular Characterization Division, RIKEN
    2000
    Head, Molecular Characterization Division, RIKEN
    2003
    Team Leader, Molecular Characterization Team, ADSC, RIKEN
    2008
    Team Head, Molecular Characterization Team, ATSD, RIKEN
    2009
    Team Head, Molecular Characterization Team, CBCF, RIKEN (-current)

Outline

Molecular Characterization Team

Our team provides diverse research support for molecular characterization. We develop new methods and technologies for structural elucidation of new organic compounds that are important in chemistry and related scientific fields such as chemical biology research. We also maintain and operate MS, NMR and CD instruments for researchers. Our research support activities include training on machine use, technical assistance, acquisition of spectral data and data analysis for structural determination of organic compounds. We support and collaborate with many research groups and continue to improve our capability and methodology for structural determination by spectroscopic analysis together with organic synthesis.

Recent Research Topic

Structural revision of some natural products
Fig. 1: Structural revision of some natural products

Selected Publications

  1. Y. Izuchi, H. Koshino, Y. Hongo, N. Kanomata, S. Takahashi, Synthesis and structural revision of phomopsin B, a novel polyketide carrying a 10-membered cyclic-ether ring, Org. Lett. 2011, 13, 3360.
  2. K. Ogawa, T. Nakamura, Y. Terada, K. Kose, T. Haishi, Development of a magnetic resonance microscope using a high Tc bulk superconducting magnet, Appl. Phys. Lett. 2011, 98, 234101.
  3. Y. Izuchi, et al. Formal total synthesis of aspergillide A, Tetrahedron Asymmetry 2011, 22, 246.
  4. S. -M. Cho, B. -S. Yun, I. -D. Yoo, H. Koshino, Structure of fomitellan A, a mannofuogalactan from the fruiting bodies of Formitella fraxinea, Bioorg. Med. Chem. Lett. 2011, 21, 204.
  5. H. Tani, et al. Inhibitory activity of Brazilin green propolis components and their derivatives on the release of cys-leukotrienes, Bioorg. Med. Chem. 2010, 18, 151.
  6. Y. Q. Ye, et al. Expeditious synthesis of vialinin B, an extremely potent inhibitor of TNF-α production, Org. Lett. 2009, 11, 5074.
  7. Y. Q. Ye, et al. Structural revision of thelephantin G by total synthesis and the inhibitory activity against TNF-α production, J. Org. Chem. 2009, 74, 4642.
  8. H. Tani, et al. Isolation of (E)-9,10-dihydroxy-2-decenoic acid from royal jelly and determination of the absolute configuration by chemical synthesis, Tetrahedron Asymmetry 2009, 20, 457.
  9. M. Malon, T. Imakubo, H. Koshino, 1H, 13C and 77Se NMR study of tetraselenafulvalene derivatives supported by novel H(Se)C and H(C)Se triple-resonance experiments at natural abundance, Magn. Reson. Chem. 2008, 46, 150.
  10. Y. Hongo, A. Sato, T. Nakamura, Factors governing peptide backbone cleavages in electron capture dissociation of triantennary complex-type N-glycosylated peptide, J. Mass Spectrom. Soc. Jpn. 2007, 55, 279.

Core Members

Principal Investigator add delete
Hiroyuki Koshino Team Head    
Staff Scientist add delete
Shun-ya Takahashi Senior Research Scientist    
Takashi Nakamura Senior Technical Scientist    
Takemichi Nakamura Senior Research Scientist    
Yayoi Hongo Technical Scientist    
Postdoctoral Fellow add delete
Student Trainee add delete
Technical Assistant add delete
Administrative Assistant add delete
Visiting Research Staff add delete
Other Staff add delete
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