
To promote “Chemical Biological Research” that aims to elucidate biological phenomena using chemical compounds as starting materials, chemical libraries and databases that describe the chemical and biological information of the libraries must be appropriately maintained.
Our facility will construct chemical libraries and databases through the genetic and organic chemical research of secondary metabolites from actinomycetes and fungi.
We will also promote basic research to validate the usefulness of the chemical library, to identify the molecular targets of active compounds, and to elucidate the mechanisms behind the actions of the active compounds in the libraries.
We will continue to maintain the infrastructure for chemical biological studies.
A chemical library is an indispensable tool for the promotion of drug-discovery in the strategy of chemical biology. To ensure utilization and application of the chemical library, we are developing the foundation of a chemical bank, the “Natural Products Depository (NPDepo).”
We develop systems to construct a chemical library of microbial metabolites with varied structures and biological activities. We are trying to diversify microbial metabolites by modifying gene clusters in microorganisms. In this project, we utilize Streptomyces genome sequence information and a fungal genome sequence database.
A good chemical library should contain many compounds with a wide range of useful biological activities; therefore our team validates the activities of the compounds in NPDepo by actual screening of the library through various assay systems.
Our team provides diverse research support for molecular characterization. We develop new methods and technologies for structural elucidation of new organic compounds that are important in chemistry and related scientific fields such as chemical biology research.
Protein is one of the most important molecules of life and our purpose is to clarify the correlation of a gene and its functions by examining its protein structure. To that end, we have been developing characterization methods of protein post-translational modifications (PTMs) in the latest proteomics technology.
This cooperation team carries out chemical biology research under the general agreement between RIKEN and the Korea Research Institute for Bioscience and Biotechnology (KRIBB).
Our team aims to isolate novel biological active compounds from tropical plants found in Southeast Asia, particularly in Malaysia.
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| Hiroyuki Osada | Laboratory Director |
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Please see Research Team page for other members.