Chemical Genomics Research Group

Group Director

Minoru Yoshida

  • D.Agr.
  • Minoru Yoshida
  • Brief resume
    1986
    Ph.D., University of Tokyo
    1986
    Assistant Professor, University of Tokyo
    1995
    Associate Professor, University of Tokyo
    2002
    Chief Scientist, Chemical Genetics Laboratory, RIKEN (-current)
    2002
    Visiting Professor, University of Tokyo (-current)
    2003
    Visiting Professor, Saitama University (-current)
    2008
    Group Director, Chemical Genomics Research Group, RIKEN (-current)
    2011
    Visiting Professor, Kyoto University (-current)

Outline

Chemical biology using chemistry as leverage has unraveled complex biological functions and contributed much to the discovery of novel phenomena and their underlying mechanisms. Thanks to recent technical advances, chemical biology has been able to develop a more comprehensive approach to “Chemical Genomics.” Our group focuses on the development of a variety of original assay systems using newly identified genes, proteins and cell lines, and on the discovery of unique compounds (molecular ligands) that target specific biological molecules. Based on the activity of such novel molecular ligands, our efforts will be directed toward the identification of their target molecules and the elucidation of the roles of their biological functions. Our goal is to more deeply understand biological systems and to construct the bases for drug discovery.

Selected Publications

  1. S. Nishimura, et al. Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling, Nat. Chem. Biol. 2010, 6, 519.
  2. T. Maekawa, W. Jin, S. Ishii, The role of ATF-2 family transcription factors in adipocyte differentiation: antiobesity effects of p38 inhibitors, Mol. Cell. Biol. 2010, 30, 613.
  3. M. Ohkubo, G. Hirai, M. Sodeoka, Synthesis of the DFGH ring system of Type B Physalins: Highly Oxygenated, Cage-Shaped Molecules, Angew. Chem. Int. Ed. 2009, 48, 3862.
  4. K. Sasaki, T. Ito, N. Nishino, S. Khochbin, M. Yoshida, Real-time imaging of histone H4 hyperacetylation in living cells, Proc. Natl Acad. Sci. USA 2009, 106, 16257.
  5. C. H. Ho, et al. A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds, Nature Biotechnol. 2009, 27, 369.
  6. T. Watanabe, et al. Genetic analysis of glucosidase II β-subunit in trimming of high-mannose-type glycans, Glycobiology 2009, 19, 834.
  7. I. Fukuda, et al. Kerriamycin B inhibits protein SUMOylation, J. Antibiotics, 2009, 62, 221.
  8. H. Tatsukawa, et al. Role of transglutaminase 2 in liver injury via crosslinking and silencing of transcription factor, Sp1, Gastroenterology, 2009, 136, 1783.
  9. I. Fukuda, et al. Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate, Chem. Biol. 2009, 16, 133.
  10. Y. Yashiroda, A. Matsuyama, M. Yoshida, New insights into chemical biology from ORFeome libraries, Curr. Opin. Chem. Biol. 2008, 12, 55.

Core Members

Principal Investigator add delete
Minoru Yoshida Group Director    
Staff Scientist add delete
Postdoctoral Fellow add delete
Yasushi Takemoto Visiting Researcher (Visiting Researcher, Molecular Ligand Discovery Research Team)    
Student Trainee add delete
Technical Assistant add delete
Administrative Assistant add delete
Visiting Research Staff add delete
Other Staff add delete

( ) indicates primary affiliation in RIKEN. Please see Research Team page for other members.

Back to Top