Genome Science Laboratory

Chief Scientist

Yoshihide Hayashizaki

  • M.D., Ph.D.
  • Yoshihide Hayashizaki
  • Brief resume
    1982
    M.D. in Osaka University, Japan
    1986
    Ph. D. in Osaka University, Japan
    1994
    Senior Research Scientist, RIKEN Tsukuba Life Science Center, Japan
    1995
    Chief Scientist, Genome Science Laboratory, RIKEN, Japan
    1998
    Project Director, Genome Exploration Research Group, Genomic Sciences Center, RIKEN
    2001
    Professor at Yokohama City University, Graduate school of Integrated Science (-current)
    2003
    Foreign Adjunctive Professor, Karolinska Institute, Sweden (-current)
    2003
    Honorary Professor, University of Queensland, Australia (-current)
    2008
    Director, Omics Science Center, RIKEN (-current)

Outline

The Genome Science Laboratory has been developing basic technologies for functional genomics and exploring the genes resources. Our main activity, the establishment of the mouse full-length cDNA encyclopedia, has been carried over by Genome Exploration Research Group, Genomic Sciences Center which started in October, 1998. Our laboratory is now working on the development of new full-length cDNA library construction technologies to collect even more rarely expressed genes. Moreover, we are focusing on the analysis of alternatively splices mRNA, which do produce various functional proteins, and constructing the so-called super long cDNA libraries (a good part of disease-related genes produce very long mRNAs, and therefore such kind of libraries are necessary), and have developed the CAGE (Cap Analysis Gene Expression) technology which allows collecting transcriptional starting points. The development of these key technologies has been contributing to discover disease-related genes, pharmaceutically relevant target genes and other commercially valuable targets. We have established a collaboration networks with many institutes and universities in Japan and abroad, and have used our originally developed technologies to obtain biological insights from disease models. With the Genome Network Project, in collaboration with the Genome Exploration Research Group, we are applying the high throughput system of CAGE to comprehensively collect transcriptome starting sites in order to map gene expression regulatory elements. These data constitute to be a basic platform to analyze the Genome Network.

Selected Publications

  1. Y. Mitani, et al. Rapid SNP diagnostics using asymmetric isothermal amplification and a new mismatch-suppression technology, Nat Methods. 2007, 4(3), 257.
  2. P. Carninci, et al. Genome-wide analysis of mammalian promoter architecture and evolution, Nat Genet. 2006, 38, 626.
  3. The FANTOM Consortium, RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome, Science 2005, 309, 1559.
  4. RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium, Antisense Transcription in the Mammalian Transcriptome, Science 2005, 309, 1564.
  5. T. Shiraki, et al. Cap analysis gene expression for high-throughput analysis of transcriptional starting point and identification of promoter usage, Proc. Natl Acad. Sci. USA 2003, 100, 15776.
  6. The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNA, Nature 2002, 420, 563.
  7. The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium, Functional annotation of 21,076 sequenced mouse cDNAs prepared from full-length enriched libraries, Nature 2001, 409, 685.

Core Members

Principal Investigator add delete
Yoshihide Hayashizaki Chief Scientist (Director, RIKEN Omics Science Center)    
Staff Scientist add delete
Jun Kawai Vice Chief Scientist    
Piero Carninci Senior Research Scientist    
Masayoshi Ito Senior Research Scientist    
Postdoctoral Fellow add delete
Student Trainee add delete
Technical Assistant add delete
Administrative Assistant add delete
Visiting Research Staff add delete
Other Staff add delete

( ) indicates primary affiliation in RIKEN.

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